Website news (Reporter: Yang Xue) Recently, original breakthrough has been achieved in research on interaction of virus and host cell by research group led by Professor Cheng Mingzhou of the School of Life Science. The result is published on the subordinate journal of Cell, Cell Host & Microbe. The doctoral student Ding Binbin is the first author, and Professor Cheng Mingzhou is the corresponding author.
The research discovered for the first time that, human parainfluenza virus can "hijack" synaptophysin, inhibit the fusion of autophagosome-lysosome, so as to facilitate the generation of virion. Dr. Mathias Faure of International Infection Biology Research Center made a comment to the paper in the Cell Host & Microbe of the same session.
Human parainfluenza virus is one of the main pathogenies, which can cause acute bronchiolitis, pneumonia and asthma. At present, as the deterioration of air quality, and the increase of fog and haze over the country, the injury of respiratory disease is intensified. However, there is still a lack of effective vaccine and antiviral drug to prevent and cure infection of human parainfluenza virus. So, uncovering the pathological mechanism of infection of human parainfluenza virus is the molecular basis for research and development of anti-human parainfluenza virus drug and vaccine.
With human parainfluenza virus as model virus, the research group led by Cheng Mingzhou found that, the human parainfluenza virus can block the fusion of autophagosome-lysosome. The research shows that, the polymerase cofactor of the virus, through interaction with a key synaptophysin, blocks its function, and inhibit autophagosome-lysosome fusion, so that facilitates the generation of the virion. The discovery not only contributes to the research of interaction of unsegmented negative-strand RNA virus and host, but also provides a totally new direction for research on how the virus blocks the membrane fusion in cell.
Additionally, the research group has made a series of significant progress in replication of un-segmented negative-strand RNA virus. The research results are published on authoritative journal in the field of virology, Journal of Virology.
(Editor: Fu Xiaoge)