The Latest Research Results of Shu Hongbing Research Group has been Published in Subordinate Journal of Cell
Website news (Reporter: Yang Xue) On October 8, the latest research result of Research Group led by Academician Shu Hongbing of the School of Life Science in the field of antiviral innate immunity was published in the subordinate journal of Cell, Cell Host & Microbe. The doctoral student Zhou Qian is the first author, and the corresponding authors are Shu Hongbing and Wang Yanyi, the researcher of Wuhan Institute of Virology, Chinese Academic of Science.
The title of the paper is The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered,MITA/STING-Dependent Innate Immune Signaling. The research is significant to understand the DNA virus-induced type-I interferon expression and the molecular mechanism of antiviral innate immunity.
According to introduction, virus is the simplest organism, which can only replicate and survive through infecting host cells. Innate immunity is the first defensive line to resist virus infection, which plays a key role in antiviral immunity of host cell. The first key step of innate immunity response of host cell is that the virus infection induces the synthesis and excretion of IFN-I by the cell. IFN-I induces antiviral effect through multiple ways. Shu Hongbing Research Group and Glenn Barber Research Group of University of Miami reported in 2008 simultaneously the adaptor protein MITA/STING which plays an important role in the synthesis and excretion of IFN-I induced by virus infection. The research has drawn extensive attention, become a research hotspot in immunology immediately, and the paper become highly cited.
This research identified through expression cloning that, the endoplasmic reticulum protein ZDHHC1 is positive regulator of virus-triggered and MITA/STING-dependent innate immunity signal transduction. In the experiment, they use gene knock-out mouse model verified that ZDHHC1 plays an important role in innate immunity induced by DNA virus (such as herpes simplex virus type I, HSV-1). After infection of the virus, in the serum of ZDHHC1 gene knock-out mouse, the expression of IFN-I decreased, and the virus titer in brain tissue increased, which caused the mouse more likely to die. The experiment of biochemistry and cell biology shows that, ZDHHC1 functions through interaction with MITA.
This is another new result of Shu Hongbing Research Group after publishing 7 papers in international authoritative journals such as Proceedings of the National Academy of Sciences, Plos Pathogens, etc. Since 2005, Shu Hongbing and his team have achieved noticeable progress in the field of antiviral innate immunity response. They have published more than 80 papers in famous international journals, such as Immunity, Molecular Cell, Cell Host & Microbe, PNAS, Plos Pathogens, Cell Research. The highest case, a paper was cited for nearly 800 times by SCI.